Synergistic antibacterial activity of ciprofloxacin-loaded silver and mesoporous silica core/shell nanoparticles
DOI:
https://doi.org/10.22353/mjeas.v7i1.9635Keywords:
Ag@MSNs, ciprofloxacin, synergistic effectAbstract
The misuse and overuse of antibiotics have led to the rise of antibiotic-resistant microorganisms, which are projected to cause approximately 10 million deaths annually by 2050, surpassing cancer-related mortality. This growing crisis requires the development of new antibacterial strategies. Nanoparticles (NPs) have emerged as promising antimicrobial agents, with silver nanoparticles (AgNPs) demonstrating potent antibacterial activity through mechanisms such as controlled silver ion release, increased bacterial membrane permeability, and reactive oxygen species (ROS) generation. In this study, ciprofloxacin-loaded silver and mesoporous silica core/shell
nanoparticles (CIPRO-Ag@MSNs) exhibited synergistic antibacterial effects against both Gram-positive bacteria (Staphylococcus aureus and Micrococcus luteus) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa), significantly improving the efficacy of ciprofloxacin. Notably, mesoporous silica-coated silver nanoparticles (Ag@MSNs) improved biocompatibility by reducing excessive bacterial killing, highlighting their potential as a safe and effective nanosystem for bacterial infection treatment.
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